magtivio designs, develops and manufactures two types of silica enclosed iron oxides magnetic beads.
Designed in a composite, porous structure. These are easy to resuspend and exhibit low sedimentation rates.
Manufactured with a relatively dense core-shell structure this bead type has strong magnetic properties, making it more suited for large volume and viscous samples.
Terminal functionalized groups can be connected to the silica coating of both magnetic bead types.
Our magnetic beads and complete kits, available under the brand names MagSi and MagSiMUS, can be used for different modes of selection.
Positive selection (MagSi)
The classic bind-wash-elute/react principle. Biological molecules are bound to the surface of the beads, contaminants are washed away while the beads are held to a magnet, after which the molecules of interest are eluted from the beads again. The purified, biological molecules (often DNA or RNA) are now ready for downstream processing. Alternatively, this positive selection mode can also be used in e.g., immunoassays.
Negative selection (depletion) (MagSiMUS)
Contaminants in the sample are precipitated towards the magnetic beads’ surface, while the biological molecules/analytes of interest remain behind in the supernatant for further analysis.
Covid-19 RNA extractions